FHL-2 Suppresses VEGF-Induced Phosphatidylinositol 3-Kinase/Akt Activation via Interaction With Sphingosine Kinase-1 | Zendy

Hiroki Hayashi | Zendy; Hironori Nakagami | Zendy; Yoichi Takami | Zendy; Hiroshi Koriyama | Zendy; Masaki Mori | Zendy; Katsuto Tamai | Zendy; Jianxin Sun | Zendy; Kaori Nagao | Zendy; Ryuichi Morishita | Zendy; Yasufumi Kaneda | Zendy

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FHL-2 Suppresses VEGF-Induced Phosphatidylinositol 3-Kinase/Akt Activation via Interaction With Sphingosine Kinase-1

Author(s) -

Hiroki Hayashi,

Hironori Nakagami,

Yoichi Takami,

Hiroshi Koriyama,

Masaki Mori,

Katsuto Tamai,

Jianxin Sun,

Kaori Nagao,

Ryuichi Morishita,

Yasufumi Kaneda

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.178541

Subject(s) - sphingosine kinase 1 , protein kinase b , sphingosine , microbiology and biotechnology , phosphatidylinositol , pi3k/akt/mtor pathway , sphingosine 1 phosphate , vascular endothelial growth factor , phosphorylation , signal transduction , sphingosine kinase , biology , chemistry , kinase , cancer research , biochemistry , receptor , vegf receptors

In the functional screening of a human heart cDNA library to identify a novel antiangiogenic factor, the prime candidate gene was "four-and-a-half LIM only protein-2" (FHL-2). The goal of this study is to clear the mechanism of antiangiogenic signaling of FHL-2 in endothelial cells (ECs).

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