Identification of Quantitative Trait Loci for Fibrin Clot Phenotypes
Author(s) -
Frances M. K. Williams,
Angela M. Carter,
Bernet Kato,
Mario Falchi,
Lise Bathum,
Gabriela Surdulescu,
Kirsten Ohm Kyvik,
Aarno Palotie,
Tim D. Spector,
Peter J. Grant
Publication year - 2009
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.108.178103
Subject(s) - fibrin , heritability , phenotype , fibrinogen , biology , quantitative trait locus , genetics , gene , immunology , biochemistry
Fibrin makes up the structural basis of an occlusive arterial thrombus, and variability in fibrin phenotype relates to cardiovascular risk. The aims of the current study from the EU consortium EuroCLOT were to (1) determine the heritability of fibrin phenotypes and (2) identify QTLs associated with fibrin phenotypes.
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