Soluble N-Cadherin Overexpression Reduces Features of Atherosclerotic Plaque Instability | Zendy

Cressida A. Lyon | Zendy; Jason L. Johnson | Zendy; Helen Williams | Zendy; Graciela B. SalaNewby | Zendy; Sarah J. George | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Soluble N-Cadherin Overexpression Reduces Features of Atherosclerotic Plaque Instability

Author(s) -

Cressida A. Lyon,

Jason L. Johnson,

Helen Williams,

Graciela B. SalaNewby,

Sarah J. George

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.178087

Subject(s) - apoptosis , macrophage , chemistry , microbiology and biotechnology , in vitro , cancer research , biology , biochemistry

Vascular smooth muscle cell (VSMC) apoptosis contributes to atherosclerotic plaque instability and myocardial infarction. Consequently, reducing VSMC apoptosis may be beneficial for reducing plaque instability and acute coronary events. We previously demonstrated that N-cadherin, a cell-cell adhesion molecule, reduces VSMC apoptosis in vitro. In this study, we examined whether a soluble form of N-cadherin (SNC) affected VSMC apoptosis and plaque stability.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research