Open AccessOverexpression of Adiponectin Receptors Potentiates the Antiinflammatory Action of Subeffective Dose of Globular Adiponectin in Vascular Endothelial Cells
Author(s) -
Peng Zhang,
Ying Wang,
Yanbo Fan,
Zhihui Tang,
Nanping Wang
Publication year - 2008
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.108.178061
Subject(s) - adiponectin , receptor , action (physics) , microbiology and biotechnology , pharmacology , endocrinology , chemistry , medicine , biology , physics , insulin resistance , quantum mechanics , insulin
A decreased plasma level of adiponectin is associated with obesity and metabolic syndrome and correlated with endothelial dysfunction. This study aimed to investigate the regulated expression of the newly identified adiponectin receptors (AdipoR1 and 2) and their roles in the endothelial expression of intercellular adhesion molecule-1 (ICAM-1) in response to tumor necrosis factor (TNF)-alpha.
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