Involvement of Native TRPC3 Proteins in ATP-Dependent Expression of VCAM-1 and Monocyte Adherence in Coronary Artery Endothelial Cells | Zendy

Kathryn Smedlund | Zendy; Guillermo Vázquez | Zendy

Open Access

Involvement of Native TRPC3 Proteins in ATP-Dependent Expression of VCAM-1 and Monocyte Adherence in Coronary Artery Endothelial Cells

Author(s) -

Kathryn Smedlund,

Guillermo Vázquez

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.175356

Subject(s) - trpc3 , monocyte , microbiology and biotechnology , cell adhesion molecule , vcam 1 , downregulation and upregulation , endothelium , cell adhesion , biology , signal transduction , chemistry , immunology , biochemistry , endocrinology , cell , icam 1 , receptor , transient receptor potential channel , gene , trpc

Background- Vascular cell adhesion molecule-1 (VCAM-1) is critical in monocyte recruitment to the endothelium, a key event in development of atherosclerotic lesions. Stimulation of human coronary artery endothelial cells (HCAECs) with ATP positively modulates VCAM-1 expression and function through a mechanism involving Ca(2+) signaling. We here examined the role of Ca(2+) influx and native TRPC3 channels in that mechanism.

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