Oxidized LDL-Mediated Macrophage Survival Involves Elongation Factor-2 Kinase | Zendy

Johnny H. Chen | Zendy; Maziar Riazy | Zendy; Ewan M. Smith | Zendy; Christopher G. Proud | Zendy; Urs P. Steinbrecher | Zendy; Vincent Duronio | Zendy

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Oxidized LDL-Mediated Macrophage Survival Involves Elongation Factor-2 Kinase

Author(s) -

Johnny H. Chen,

Maziar Riazy,

Ewan M. Smith,

Christopher G. Proud,

Urs P. Steinbrecher,

Vincent Duronio

Publication year - 2009

Publication title -

arteriosclerosis, thrombosis, and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.174599

Subject(s) - ask1 , microbiology and biotechnology , kinase , protein kinase a , cyclin dependent kinase 9 , map kinase kinase kinase , mitogen activated protein kinase kinase , cyclin dependent kinase 2 , chemistry , p38 mitogen activated protein kinases , biology , cancer research

Macrophage survival and proliferation is believed to be a contributing factor in the development of early atherosclerotic lesions. Oxidized low density lipoprotein (oxLDL), a key mediator in the pathogenesis of this disease, has been shown to block apoptosis in macrophages deprived of growth factor. In this report, we investigate the mechanism of oxLDL-mediated macrophage survival.

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