Open AccessNox4 Acts as a Switch Between Differentiation and Proliferation in Preadipocytes
Author(s) -
Katrin Schröder,
Katalin Wandzioch,
Ina Helmcke,
Ralf P. Brandes
Publication year - 2008
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.108.174219
Subject(s) - nox4 , nox1 , insulin , insulin receptor , microbiology and biotechnology , downregulation and upregulation , nadph oxidase , phosphorylation , chemistry , irs1 , reactive oxygen species , signal transduction , biology , medicine , endocrinology , biochemistry , insulin resistance , gene
Insulin promotes differentiation of preadipocytes into adipocytes. Insulin also stimulates reactive oxygen species (ROS) production, and the NADPH oxidases Nox1 and Nox4 are important sources of ROS. We determined in human and mouse preadipocytes whether Nox proteins contribute to ROS formation and differentiation in response to insulin.
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