Open AccessSuppressors of Cytokine Signaling Modulate JAK/STAT-Mediated Cell Responses During Atherosclerosis
Author(s) -
Guadalupe Ortiz-Muñoz,
José Luis MartínVentura,
Purificación Hernández-Vargas,
Beñat Mallavia,
Virginia López-Parra,
Óscar LópezFranco,
Begoña MuñozGarcía,
P. FernándezVizarra,
Luís Ortega,
Jesús Egido,
Carmen GómezGuerrero
Publication year - 2009
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.108.173781
Subject(s) - socs3 , janus kinase , suppressor of cytokine signaling 1 , stat protein , stat , suppressor of cytokine signalling , jak stat signaling pathway , cytokine , signal transduction , proinflammatory cytokine , microbiology and biotechnology , biology , foam cell , stat3 , chemokine , cancer research , immune system , inflammation , immunology , macrophage , tyrosine kinase , suppressor , biochemistry , cancer , genetics , in vitro
Suppressors of cytokine signaling (SOCS) proteins are intracellular regulators of receptor signal transduction, mainly Janus kinase/signal transducers and activators of transcription (JAK/STAT). We investigated the effects of SOCS modulation on the JAK/STAT-dependent responses in vascular cells, and their implication in atherosclerotic plaque development.
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