Open AccessDeficiency and Inhibition of Cathepsin K Reduce Body Weight Gain and Increase Glucose Metabolism in Mice
Author(s) -
Min Yang,
Jiusong Sun,
Tinghu Zhang,
Jian Liu,
Jie Zhang,
Michael Shi,
Froogh Darakhshan,
Michèle Guerre-Millo,
Karine Clément,
Bruce D. Gelb,
Gregory Dolgnov,
GuoPing Shi
Publication year - 2008
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.108.172320
Subject(s) - medicine , endocrinology , adipogenesis , adipose tissue , cathepsin k , fibronectin , cathepsin , weight gain , biology , chemistry , extracellular matrix , body weight , biochemistry , enzyme , receptor , osteoclast
Previous studies demonstrated increased levels of cysteine proteases cathepsins in serum and adipose tissues from obese patients. We now provide evidence from a mouse model of obesity to suggest a direct participation of cathepsin K (CatK) in mouse body weight gain and glucose metabolism.
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