Open AccessIntegrins
Author(s) -
Rita Silva,
Gabriela D’Amico,
Kairbaan HodivalaDilke,
Louise E. Reynolds
Publication year - 2008
Publication title -
arteriosclerosis, thrombosis, and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.108.172015
Subject(s) - angiogenesis , mural cell , integrin , cell adhesion molecule , pathogenesis , endothelial stem cell , cell adhesion , cancer research , medicine , microbiology and biotechnology , immunology , biology , pathology , cell , in vitro , genetics
Angiogenesis, the formation of new blood vessels from preexisting vasculature, contributes to the pathogenesis of many disorders, including ischemic diseases and cancer. Integrins are cell adhesion molecules that are expressed on the surface of endothelial cells and pericytes, making them potential targets for antiangiogenic therapy. Here we review the contribution of endothelial and mural cell integrins to angiogenesis and highlight their potential as antiangiogenesis targets.