Core2 1-6-N-Glucosaminyltransferase-I Is Crucial for the Formation of Atherosclerotic Lesions in Apolipoprotein E–Deficient Mice | Zendy

Huan Wang | Zendy; Rong Tang | Zendy; Weiyu Zhang | Zendy; Karine Amirikian | Zendy; Zhen Geng | Zendy; JianGuo Geng | Zendy; Robert P. Hebbel | Zendy; Lijun Xia | Zendy; Jamey D. Marth | Zendy; Minoru Fukuda | Zendy; Shigeki Katoh | Zendy; Yuqing Huo | Zendy

Open Access

Core2 1-6-N-Glucosaminyltransferase-I Is Crucial for the Formation of Atherosclerotic Lesions in Apolipoprotein E–Deficient Mice

Author(s) -

Huan Wang,

Rong Tang,

Weiyu Zhang,

Karine Amirikian,

Zhen Geng,

JianGuo Geng,

Robert P. Hebbel,

Lijun Xia,

Jamey D. Marth,

Minoru Fukuda,

Shigeki Katoh,

Yuqing Huo

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.170969

Subject(s) - macrophage , bone marrow , apolipoprotein e , lesion , monocyte , peritoneal cavity , apolipoprotein b , flow cytometry , in vitro , cell adhesion molecule , pathology , immunology , biology , medicine , chemistry , microbiology and biotechnology , disease , anatomy , cholesterol , biochemistry

Core2 1-6-N-glucosaminyltransferase-I (C2GlcNAcT-I) modification of adhesion molecules is required for optimal binding to target ligands. The objective of this study was to determine the role of C2GlcNAcT-I in the recruitment of Ly-6C(hi) monocytes to atherosclerotic lesions and in lesion formation in mice.

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