Brief Report: Accelerated Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice Lacking the Membrane-Bound Complement Regulator CD59 | Zendy

Sheng Yun | Zendy; Viola Leung | Zendy; Marina Botto | Zendy; Joseph J. Boyle | Zendy; Dorian O. Haskard | Zendy

Open Access

Brief Report: Accelerated Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice Lacking the Membrane-Bound Complement Regulator CD59

Author(s) -

Sheng Yun,

Viola Leung,

Marina Botto,

Joseph J. Boyle,

Dorian O. Haskard

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.169912

Subject(s) - regulator , cd59 , microbiology and biotechnology , ldl receptor , lipoprotein , receptor , complement system , biology , low density lipoprotein , negative regulator , immunology , medicine , endocrinology , chemistry , cholesterol , antibody , biochemistry , signal transduction , gene

Whereas studies in humans and animal models have suggested a role for complement activation in atherosclerosis, there has been little analysis of the importance of complement regulators. We tested the hypothesis that the terminal pathway inhibitor CD59 plays an essential role in limiting the proinflammatory effects of complement activation.

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