Open AccessTriglyceride-Rich Lipoprotein-Associated Apolipoprotein C-III Production Is Stimulated by Plasma Free Fatty Acids in Humans
Author(s) -
Mirjana Pavlic,
René Valéro,
Hélène Duez,
Changting Xiao,
Linda Szeto,
Bruce W. Patterson,
Gary F. Lewis
Publication year - 2008
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.108.169383
Subject(s) - apolipoprotein b , triglyceride , lipoprotein , medicine , lipoprotein(a) , apolipoprotein c2 , endocrinology , plasma lipoprotein , very low density lipoprotein , cholesterol , chemistry , biology
Insulin resistant states are associated with increased fatty acid flux to liver and intestine, which stimulates the production of triglyceride-rich lipoproteins (TRL). ApoC-III production and plasma and TRL concentrations are increased in insulin resistance and may contribute to the hypertriglyceridemia of these conditions. The mechanism underlying that increase is not known, but because apoC-III and VLDL production are closely linked we hypothesized that FFAs may stimulate TRL apoC-III production.
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