Ninein Is Expressed in the Cytoplasm of Angiogenic Tip-Cells and Regulates Tubular Morphogenesis of Endothelial Cells
Author(s) -
Tarô Matsumoto,
Petter Schiller,
Lothar C. Dieterich,
Fuad Bahram,
Yuji Iribe,
Ulf Hellman,
Charlotte Wikner,
Gordon K. Chan,
Lena ClaessonWelsh,
Anna Dimberg
Publication year - 2008
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.108.169128
Subject(s) - angiogenesis , morphogenesis , microbiology and biotechnology , biology , endothelial stem cell , cytoplasm , sprouting angiogenesis , neovascularization , cancer research , biochemistry , gene , in vitro
Angiogenesis is an integral part of many physiological processes but may also aggravate pathological conditions such as cancer. Development of effective angiogenesis inhibitors requires a thorough understanding of the molecular mechanisms regulating vessel formation. The aim of this project was to identify proteins that regulate tubular morphogenesis of endothelial cells.
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