A Novel Variant in the Platelet Endothelial Aggregation Receptor-1 Gene Is Associated With Increased Platelet Aggregability | Zendy

J. Enrique HerreraGaleano | Zendy; Diane M. Becker | Zendy; Alexander F. Wilson | Zendy; Lisa R. Yanek | Zendy; Paul F. Bray | Zendy; Dhananjay Vaidya | Zendy; Nauder Faraday | Zendy; Lewis C. Becker | Zendy

Open Access

A Novel Variant in the Platelet Endothelial Aggregation Receptor-1 Gene Is Associated With Increased Platelet Aggregability

Author(s) -

J. Enrique HerreraGaleano,

Diane M. Becker,

Alexander F. Wilson,

Lisa R. Yanek,

Paul F. Bray,

Dhananjay Vaidya,

Nauder Faraday,

Lewis C. Becker

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.168971

Subject(s) - single nucleotide polymorphism , allele , platelet , snp , locus (genetics) , genotype , medicine , aspirin , allele frequency , endocrinology , agonist , biology , genetics , receptor , gene

Platelet endothelial aggregation receptor-1 (PEAR1) is a recently identified platelet transmembrane protein that becomes activated by platelet contact. We looked for novel genetic variants in PEAR1 and studied their association with agonist-induced native platelet aggregation and with the inhibitory effect of aspirin on platelets.

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