Open AccessAldosterone and Angiotensin II Synergistically Stimulate Migration in Vascular Smooth Muscle Cells Through c-Src-Regulated Redox-Sensitive RhoA Pathways
Author(s) -
Augusto C. Montezano,
Gláucia E. Callera,
Álvaro Yogi,
Ying He,
Rita C. Tostes,
Gang He,
Ernesto L. Schiffrin,
Rhian M. Touyz
Publication year - 2008
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.108.168021
Subject(s) - rhoa , aldosterone , vascular smooth muscle , angiotensin ii , redox , proto oncogene tyrosine protein kinase src , chemistry , medicine , microbiology and biotechnology , endocrinology , renin–angiotensin system , myocyte , smooth muscle , signal transduction , biology , receptor , organic chemistry , blood pressure
Synergistic interactions between aldosterone (Aldo) and angiotensin II (Ang II) have been implicated in vascular inflammation, fibrosis, and remodeling. Molecular mechanisms underlying this are unclear. We tested the hypothesis that c-Src activation, through receptor tyrosine kinase transactivation, is critically involved in synergistic interactions between Aldo and Ang II and that it is upstream of promigratory signaling pathways in vascular smooth muscle cells (VSMCs).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom