Estrogen-Stimulated Endothelial Repair Requires Osteopontin | Zendy

Lætitia Lam Shang Leen | Zendy; Cédric Filipe | Zendy; Audrey Billon | Zendy; Barbara GarmySusini | Zendy; Sandra Jalvy | Zendy; Fanny Robbesyn | Zendy; Danièle Daret | Zendy; Cécile Allières | Zendy; Susan R. Rittling | Zendy; Nikos Werner | Zendy; Georg Nickenig | Zendy; Urban Deutsch | Zendy; Cécile Duplaà | Zendy; Pascale Dufourcq | Zendy; Françoise Lenfant | Zendy; Claude Des̀granges | Zendy; JeanFrançois Arnal | Zendy; AlainPierre Gadeau | Zendy

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Estrogen-Stimulated Endothelial Repair Requires Osteopontin

Author(s) -

Lætitia Lam Shang Leen,

Cédric Filipe,

Audrey Billon,

Barbara GarmySusini,

Sandra Jalvy,

Fanny Robbesyn,

Danièle Daret,

Cécile Allières,

Susan R. Rittling,

Nikos Werner,

Georg Nickenig,

Urban Deutsch,

Cécile Duplaà,

Pascale Dufourcq,

Françoise Lenfant,

Claude Des̀granges,

JeanFrançois Arnal,

AlainPierre Gadeau

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.167965

Subject(s) - osteopontin , bone marrow , endothelial stem cell , neointima , endothelium , transplantation , cancer research , microbiology and biotechnology , osteoblast , biology , immunology , pathology , medicine , restenosis , endocrinology , stent , biochemistry , in vitro

Estradiol (E(2)) is known to accelerate reendothelialization and thus prevent intimal thickening and in-stent restenosis after angioplasty. Transplantation experiments with ERalpha(-/-) mice have previously shown that E(2) acts through local and bone marrow cell compartments to enhance endothelial healing. However, the downstream mechanisms induced by E(2) to mediate endothelial repair are still poorly understood.

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