Monocyte Functional Responsiveness After PSGL-1–Mediated Platelet Adhesion Is Dependent on Platelet Activation Status | Zendy

Stylianos Bournazos | Zendy; Jillian Rennie | Zendy; Simon P. Hart | Zendy; Keith A.A. Fox | Zendy; Ian Dransfield | Zendy

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Monocyte Functional Responsiveness After PSGL-1–Mediated Platelet Adhesion Is Dependent on Platelet Activation Status

Author(s) -

Stylianos Bournazos,

Jillian Rennie,

Simon P. Hart,

Keith A.A. Fox,

Ian Dransfield

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.167601

Subject(s) - platelet , monocyte , proinflammatory cytokine , cd14 , thrombin , platelet activation , tissue factor , immunology , integrin alpha m , adhesion , tumor necrosis factor alpha , chemistry , microbiology and biotechnology , medicine , inflammation , biology , coagulation , flow cytometry , organic chemistry

Acute coronary diseases are characterized by elevated levels of circulating platelet-leukocyte complexes, raising the possibility that proinflammatory processes might be initiated in leukocytes after platelet adhesion. Here we examined the mechanism of platelet binding to polymorphonuclear leukocytes, monocytes, and monocyte subsets and investigated the potential functional consequences of monocyte binding to minimally activated or thrombin-activated platelets.

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