Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe −/− Mice | Zendy

Edward B. Thorp | Zendy; Dongying Cui | Zendy; D. Schrijvers | Zendy; George Kuriakose | Zendy; Ira Tabas | Zendy

Open Access

Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe ^−/− Mice

Author(s) -

Edward B. Thorp,

Dongying Cui,

D. Schrijvers,

George Kuriakose,

Ira Tabas

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.167197

Subject(s) - mertk , efferocytosis , apoptosis , biology , tunel assay , gas6 , macrophage , necrosis , pathology , phagocytosis , cancer research , apolipoprotein e , immunology , microbiology and biotechnology , medicine , receptor tyrosine kinase , signal transduction , in vitro , biochemistry , disease

Atherosclerotic plaques that are prone to disruption and acute thrombotic vascular events are characterized by large necrotic cores. Necrotic cores result from the combination of macrophage apoptosis and defective phagocytic clearance (efferocytosis) of these apoptotic cells. We previously showed that macrophages with tyrosine kinase-defective Mertk receptor (Mertk(KD)) have a defect in phagocytic clearance of apoptotic macrophages in vitro. Herein we test the hypothesis that the Mertk(KD) mutation would result in increased accumulation of apoptotic cells and promote necrotic core expansion in a mouse model of advanced atherosclerosis.

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