Open AccessAir Pollution Exposure Potentiates Hypertension Through Reactive Oxygen Species-Mediated Activation of Rho/ROCK
Author(s) -
Qinghua Sun,
Peibin Yue,
Zhekang Ying,
Arturo J. Cardounel,
Robert D. Brook,
Robert B. Devlin,
Jing-Shiang Hwang,
Jay L. Zweíer,
LungChi Chen,
Sanjay Rajagopalan
Publication year - 2008
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.108.166967
Subject(s) - fasudil , rho associated protein kinase , apocynin , angiotensin ii , vasoconstriction , phenylephrine , endocrinology , medicine , chemistry , myosin light chain phosphatase , nadph oxidase , myosin light chain kinase , myosin , oxidative stress , phosphorylation , biochemistry , blood pressure
Fine particulate matter <2.5 microm (PM(2.5)) has been implicated in vasoconstriction and potentiation of hypertension in humans. We investigated the effects of short-term exposure to PM(2.5) in the angiotensin II (AII) infusion model.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom