Open AccessTemporally Expressed PDGF and FGF-2 Regulate Embryonic Coronary Artery Formation and Growth
Author(s) -
Robert J. Tomanek,
Heidi K. Hansen,
Lance P. Christensen
Publication year - 2008
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.108.166454
Subject(s) - artery , coronary arteries , medicine , cardiology , fibroblast growth factor , anatomy , receptor
PDGF and FGF-2 are important regulators of vascular wall assembly. We tested the hypothesis that their embryonic temporal expression facilitates 2 specific events: (1) the endothelial invasion of the aortic root to form the coronary artery stems and (2) the subsequent growth and development of the arterial tree.
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