Detection of Neovessels in Atherosclerotic Plaques of Rabbits Using Dynamic Contrast Enhanced MRI and 18F-FDG PET | Zendy

Claudia Calcagno | Zendy; JeanChristophe Cornily | Zendy; Fabien Hyafil | Zendy; James H.F. Rudd | Zendy; Karen BrileySæbø | Zendy; Venkatesh Mani | Zendy; Gregg Goldschlager | Zendy; Josef Macháč | Zendy; Valentı́n Fuster | Zendy; Zahi A. Fayad | Zendy

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Detection of Neovessels in Atherosclerotic Plaques of Rabbits Using Dynamic Contrast Enhanced MRI and 18F-FDG PET

Author(s) -

Claudia Calcagno,

JeanChristophe Cornily,

Fabien Hyafil,

James H.F. Rudd,

Karen BrileySæbø,

Venkatesh Mani,

Gregg Goldschlager,

Josef Macháč,

Valentı́n Fuster,

Zahi A. Fayad

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.166173

Subject(s) - medicine , inflammation , positron emission tomography , pathology , nuclear medicine , magnetic resonance imaging , lesion , fluorodeoxyglucose , dynamic contrast enhanced mri , radiology , aorta

The association of inflammatory cells and neovessels in atherosclerosis is considered a histological hallmark of high-risk active lesions. Therefore, the development and validation of noninvasive imaging techniques that allow for the detection of inflammation and neoangiogenesis in atherosclerosis would be of major clinical interest. Our aim was to test 2 techniques, black blood dynamic contrast enhanced MRI (DCE-MRI) and 18-fluorine-fluorodeoxyglucose (18F-FDG) PET, to quantify inflammation expressed as plaque neovessels content in a rabbit model of atherosclerosis.

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