RNA Interference for Discoidin Domain Receptor 2 Attenuates Neointimal Formation in Balloon Injured Rat Carotid Artery | Zendy

KouGi Shyu | Zendy; Bao-Wei Wang | Zendy; Peiliang Kuan | Zendy; Hang Chang | Zendy

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RNA Interference for Discoidin Domain Receptor 2 Attenuates Neointimal Formation in Balloon Injured Rat Carotid Artery

Author(s) -

KouGi Shyu,

Bao-Wei Wang,

Peiliang Kuan,

Hang Chang

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.165993

Subject(s) - discoidin domain , balloon catheter , small interfering rna , medicine , rna interference , mmp2 , receptor , pathology , balloon , chemistry , rna , receptor tyrosine kinase , gene , biochemistry , metastasis , cancer

Discoidin domain receptor 2 (DDR2) plays potential roles in the regulation of collagen turnover mediated by smooth muscle cells (SMCs) in atherosclerosis. Little is known about the function of DDR2 in vascular system. We investigated whether inhibition of DDR2 by small interfering RNA (siRNA) can reduce neointimal formation after arterial injury.

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