Ultrasonic Microbubble Destruction Stimulates Therapeutic Arteriogenesis Via the CD18-Dependent Recruitment of Bone Marrow–Derived Cells | Zendy

John C. Chappell | Zendy; Ji Song | Zendy; Alexander L. Klibanov | Zendy; Richard J. Price | Zendy

Open Access

Ultrasonic Microbubble Destruction Stimulates Therapeutic Arteriogenesis Via the CD18-Dependent Recruitment of Bone Marrow–Derived Cells

Author(s) -

John C. Chappell,

Ji Song,

Alexander L. Klibanov,

Richard J. Price

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.165589

Subject(s) - arteriogenesis , bone marrow , microbubbles , angiogenesis , cd18 , skeletal muscle , hindlimb , neovascularization , femoral artery , microbiology and biotechnology , medicine , immunology , biology , integrin alpha m , ultrasound , immune system , radiology

We have previously shown that, under certain conditions, ultrasonic microbubble destruction creates arteriogenesis and angiogenesis in skeletal muscle. Here, we tested whether this neovascularization response enhances hyperemia in a rat model of arterial insufficiency and is dependent on the recruitment of bone marrow-derived cells (BMDCs) to treated tissues via a beta2 integrin (CD18)-dependent mechanism.

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