Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells | Zendy

Hidetaka Ota | Zendy; Masato Eto | Zendy; Mitsunobu R. Kano | Zendy; Sumito Ogawa | Zendy; Katsuya Iijima | Zendy; Masahiro Akishita | Zendy; Yasuyoshi Ouchi | Zendy

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Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells

Author(s) -

Hidetaka Ota,

Masato Eto,

Mitsunobu R. Kano,

Sumito Ogawa,

Katsuya Iijima,

Masahiro Akishita,

Yasuyoshi Ouchi

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.164368

Subject(s) - oxidative stress , downregulation and upregulation , senescence , cilostazol , microbiology and biotechnology , sirtuin 1 , endothelium , angiogenesis , chemistry , medicine , biology , biochemistry , gene , aspirin

Cilostazol, a selective inhibitor of PDE3, has a protective effect on endothelium after ischemic vascular damage, through production of nitric oxide (NO). The purpose of the present study was to clarify the molecular mechanisms underlying the preventive effect of treatment with cilostazol on oxidative stress-induced premature senescence in human endothelial cells.

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