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Our previous studies revealed upregulation of stanniocalcin-1 (STC1) in cardiac vessels in dilated cardiomyopathy. However, the functional significance of STC1 is unknown. The objective of this study was to determine the effects of STC1 on TNF-alpha-induced monolayer permeability of human coronary artery endothelial cells (HCAECs).

Human Stanniocalcin-1 Blocks TNF-α–Induced Monolayer Permeability in Human Coronary Artery Endothelial Cells