Human Stanniocalcin-1 Blocks TNF-α–Induced Monolayer Permeability in Human Coronary Artery Endothelial Cells | Zendy

Changyi Chen | Zendy; Md Saha Jamaluddin | Zendy; Shaoyu Yan | Zendy; David SheikhHamad | Zendy; Qizhi Yao | Zendy

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Human Stanniocalcin-1 Blocks TNF-α–Induced Monolayer Permeability in Human Coronary Artery Endothelial Cells

Author(s) -

Changyi Chen,

Md Saha Jamaluddin,

Shaoyu Yan,

David SheikhHamad,

Qizhi Yao

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.163667

Subject(s) - endothelium , coronary artery disease , tumor necrosis factor alpha , monolayer , artery , endothelial stem cell , permeability (electromagnetism) , chemistry , medicine , microbiology and biotechnology , cardiology , biology , in vitro , biochemistry , membrane

Our previous studies revealed upregulation of stanniocalcin-1 (STC1) in cardiac vessels in dilated cardiomyopathy. However, the functional significance of STC1 is unknown. The objective of this study was to determine the effects of STC1 on TNF-alpha-induced monolayer permeability of human coronary artery endothelial cells (HCAECs).

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