AP-1–Dependent Transcriptional Regulation of NADPH Oxidase in Human Aortic Smooth Muscle Cells | Zendy

Adrian Manea | Zendy; Simona A. Manea | Zendy; Anca Violeta Gafencu | Zendy; Monica Raicu | Zendy; Maya Simionescu | Zendy

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AP-1–Dependent Transcriptional Regulation of NADPH Oxidase in Human Aortic Smooth Muscle Cells

Author(s) -

Adrian Manea,

Simona A. Manea,

Anca Violeta Gafencu,

Monica Raicu,

Maya Simionescu

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.163592

Subject(s) - nadph oxidase , smooth muscle , microbiology and biotechnology , chemistry , medicine , biology , cardiology , anatomy , endocrinology , reactive oxygen species

NADPH oxidase (NADPHox) is the major source of reactive oxygen species in vascular diseases; the mechanisms of enzyme activation are not completely elucidated. AP-1 controls the expression of many genes linked to vascular smooth muscle cells (SMCs) dysfunction. In this study we searched for the role of AP-1 in the regulation of NADPHox expression and function in human aortic SMCs exposed to proinflammatory conditions.

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