TRIB3 R84 Variant Is Associated With Impaired Insulin-Mediated Nitric Oxide Production in Human Endothelial Cells | Zendy

Francesco Andreozzi | Zendy; Gloria Formoso | Zendy; Sabrina Prudente | Zendy; Marta Letizia Hribal | Zendy; Assunta Pandolfi | Zendy; Emanuele Bellacchio | Zendy; Sara Di Silvestre | Zendy; Vincenzo Trischitta | Zendy; Agostino Consoli | Zendy; Giorgio Sesti | Zendy

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TRIB3 R84 Variant Is Associated With Impaired Insulin-Mediated Nitric Oxide Production in Human Endothelial Cells

Author(s) -

Francesco Andreozzi,

Gloria Formoso,

Sabrina Prudente,

Marta Letizia Hribal,

Assunta Pandolfi,

Emanuele Bellacchio,

Sara Di Silvestre,

Vincenzo Trischitta,

Agostino Consoli,

Giorgio Sesti

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.162883

Subject(s) - protein kinase b , insulin , enos , medicine , nitric oxide , insulin receptor , umbilical vein , endocrinology , insulin resistance , biology , endothelium , phosphorylation , microbiology and biotechnology , nitric oxide synthase , biochemistry , in vitro

In the endothelium, insulin promotes nitric oxide (NO) production, through the insulin receptor/IRS-1/PI3-Kinase/Akt/eNOS signaling pathway. An inhibitor of insulin action, TRIB3, has recently been identified which affects insulin action by binding to and inhibiting Akt phosphorylation. We have recently described a Q84R gain-of-function polymorphism of TRIB3 with the R84 variant being associated with insulin resistance and an earlier age at myocardial infarction.

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