CCN1 Knockdown Suppresses Neointimal Hyperplasia in a Rat Artery Balloon Injury Model | Zendy

Hironobu Matsumae | Zendy; Yoshinori Yoshida | Zendy; Koh Ono | Zendy; Kiyonori Togi | Zendy; Katsumi Inoue | Zendy; Yutaka Furukawa | Zendy; Yasuhiro Nakashima | Zendy; Yoji Kojima | Zendy; Masakiyo Nobuyoshi | Zendy; Toru Kita | Zendy; Makoto Tanaka | Zendy

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CCN1 Knockdown Suppresses Neointimal Hyperplasia in a Rat Artery Balloon Injury Model

Author(s) -

Hironobu Matsumae,

Yoshinori Yoshida,

Koh Ono,

Kiyonori Togi,

Katsumi Inoue,

Yutaka Furukawa,

Yasuhiro Nakashima,

Yoji Kojima,

Masakiyo Nobuyoshi,

Toru Kita,

Makoto Tanaka

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.162362

Subject(s) - neointimal hyperplasia , gene knockdown , balloon , artery , neointima , cardiology , medicine , hyperplasia , chemistry , restenosis , stent , gene , biochemistry

CCN1 (Cyr61) is an extracellular matrix-associated protein involved in cell proliferation and survival. CCN1 is bound to vascular smooth muscle cells (VSMCs) via integrins and is expressed in VSMCs in atherosclerotic lesions, suggesting involvement in the regulation of vascular smooth muscle cell (VSMC) proliferation and atherosclerosis. We hypothesized that knockdown of CCN1 may inhibit VSMC proliferation and suppress neointimal hyperplasia.

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