High Glucose Enhances Transient Receptor Potential Channel Canonical Type 6–Dependent Calcium Influx in Human Platelets via Phosphatidylinositol 3-Kinase–Dependent Pathway | Zendy

Daoyan Liu | Zendy; Alexandra Maier | Zendy; Alexandra Scholze | Zendy; Ursula Rauch | Zendy; Ulrike Boltzen | Zendy; Zhigang Zhao | Zendy; Zhiming Zhu | Zendy; Martin Tepel | Zendy

Open Access

High Glucose Enhances Transient Receptor Potential Channel Canonical Type 6–Dependent Calcium Influx in Human Platelets via Phosphatidylinositol 3-Kinase–Dependent Pathway

Author(s) -

Daoyan Liu,

Alexandra Maier,

Alexandra Scholze,

Ursula Rauch,

Ulrike Boltzen,

Zhigang Zhao,

Zhiming Zhu,

Martin Tepel

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.162222

Subject(s) - trpc , trpc6 , trpc5 , wortmannin , transient receptor potential channel , phosphatidylinositol , trpc1 , medicine , endocrinology , trpc3 , platelet , ly294002 , chemistry , calcium channel , calcium , l type calcium channel , kinase , receptor , biology , biochemistry

Transient receptor potential canonical type 6 (TRPC6) channels mediating 1-oleoyl-2-acetyl-sn-glycerol (OAG)-induced calcium entry have been identified on human platelets. In the present study we tested the hypothesis that hyperglycemia increases the expression of TRPC6 channels.

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