Open AccessHDL-Associated Lysosphingolipids Inhibit NAD(P)H Oxidase-Dependent Monocyte Chemoattractant Protein-1 Production
Author(s) -
Markus Tölle,
Alicja Pawlak,
Mirjam Schuchardt,
Akira Kawamura,
Uwe J.F. Tietge,
Stefan Lorkowski,
Petra Keul,
Gerd Assmann,
Jerold Chun,
Bodo Levkau,
Markus van der Giet,
Jerzy–Roch Nofer
Publication year - 2008
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.161042
Subject(s) - nad+ kinase , chemistry , nadph oxidase , medicine , endocrinology , nad(p)h oxidase , receptor , reactive oxygen species , oxidase test , biochemistry , microbiology and biotechnology , biology , enzyme
High-density lipoprotein (HDL) levels are inversely proportional to the risk of atherosclerosis, but mechanisms of HDL atheroprotection remain unclear. Monocyte chemoatractant protein-1 (MCP-1) constitutes an early component of inflammatory response in atherosclerosis. Here we investigated the influence of HDL on MCP-1 production in vascular smooth muscle cells (VSMCs) and rat aortic explants.
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