Augmentation of Vascular Remodeling by Uncoupled Endothelial Nitric Oxide Synthase in a Mouse Model of Diabetes Mellitus | Zendy

Naoto Sasaki | Zendy; Tomoya Yamashita | Zendy; Tomofumi Takaya | Zendy; Masakazu Shinohara | Zendy; Rio Shiraki | Zendy; Masafumi Takeda | Zendy; Noriaki Emoto | Zendy; Akiko Fukatsu | Zendy; Toshio Hayashi | Zendy; Kazuhisa Ikemoto | Zendy; Takahide Nomura | Zendy; Mitsuhiro Yokoyama | Zendy; Ken–ichi Hirata | Zendy; Seinosuke Kawashima | Zendy

Open Access

Augmentation of Vascular Remodeling by Uncoupled Endothelial Nitric Oxide Synthase in a Mouse Model of Diabetes Mellitus

Author(s) -

Naoto Sasaki,

Tomoya Yamashita,

Tomofumi Takaya,

Masakazu Shinohara,

Rio Shiraki,

Masafumi Takeda,

Noriaki Emoto,

Akiko Fukatsu,

Toshio Hayashi,

Kazuhisa Ikemoto,

Takahide Nomura,

Mitsuhiro Yokoyama,

Ken–ichi Hirata,

Seinosuke Kawashima

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.107.160754

Subject(s) - diabetes mellitus , nitric oxide synthase , endothelial nitric oxide synthase , medicine , nitric oxide , cardiology , vascular disease , endocrinology , type 2 diabetes mellitus , chemistry , enos

Diabetes mellitus is associated with increased oxidative stress, which induces oxidation of tetrahydrobiopterin (BH4) in vessel wall. Without enough BH4, eNOS is uncoupled to L-arginine and produces superoxide rather than NO. We examined the role of uncoupled eNOS in vascular remodeling in diabetes.

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