Critical Role of Lipid Raft Redox Signaling Platforms in Endostatin-Induced Coronary Endothelial Dysfunction | Zendy

Si Jin | Zendy; Yang Zhang | Zendy; Fan Yi | Zendy; PinLan Li | Zendy

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Critical Role of Lipid Raft Redox Signaling Platforms in Endostatin-Induced Coronary Endothelial Dysfunction

Author(s) -

Si Jin,

Yang Zhang,

Fan Yi,

PinLan Li

Publication year - 2007

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.107.159772

Subject(s) - nadph oxidase , sphingomyelin phosphodiesterase , ceramide , lipid raft , chemistry , acid sphingomyelinase , nad(p)h oxidase , colocalization , sphingomyelin , microbiology and biotechnology , signal transduction , oxidase test , bradykinin , biochemistry , enzyme , biology , membrane , receptor , apoptosis

Endostatin (EST) was found to initiate a redox signaling cascade associated with activation of NADPH oxidase in endothelial cells (ECs). The present study tested whether EST stimulates clustering of ceramide-enriched lipid rafts (LRs), which assembles and activates NADPH oxidase to form redox signaling platforms.

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