Open AccessPromotor Polymorphisms in Leukotriene C 4 Synthase and Risk of Ischemic Cerebrovascular Disease
Author(s) -
J Freiberg,
Anne TybjærgHansen,
Henrik Sillesen,
Gorm Boje Jensen,
Børge G. Nordestgaard
Publication year - 2008
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.158873
Subject(s) - genotype , gastroenterology , medicine , hazard ratio , population , incidence (geometry) , biology , genetics , confidence interval , gene , physics , optics , environmental health
Cysteinyl leukotrienes are involved in inflammation and possibly in early carotid atherosclerosis. We tested the hypothesis that the -444 A/C and -1072 G/A polymorphisms of the leukotriene C(4) synthase associate with risk of ischemic cerebrovascular disease.
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