The Role of Osteopontin in Recovery from Hind Limb Ischemia | Zendy

Craig L. Duvall | Zendy; Daiana Weiss | Zendy; Scott T. Robinson | Zendy; Fadi M.F. Alameddine | Zendy; Robert E. Guldberg | Zendy; W. Robert Taylor | Zendy

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The Role of Osteopontin in Recovery from Hind Limb Ischemia

Author(s) -

Craig L. Duvall,

Daiana Weiss,

Scott T. Robinson,

Fadi M.F. Alameddine,

Robert E. Guldberg,

W. Robert Taylor

Publication year - 2007

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.107.158485

Subject(s) - osteopontin , arteriogenesis , hindlimb , ischemia , microbiology and biotechnology , extracellular matrix , biology , immunology , chemistry , anatomy , medicine

Osteopontin (OPN) is a highly phosphorylated extracellular matrix glycoprotein that is involved in a diversity of biological processes. In the vascular wall, OPN is produced by monocytes/macrophages, endothelial cells, and smooth muscle cells, and it is thought to mediate adhesion, migration, and survival of these cell types. In this study, we hypothesized that OPN plays a critical role in recovery from limb ischemia.

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