Upregulation of Aldose Reductase During Foam Cell Formation as Possible Link Among Diabetes, Hyperlipidemia, and Atherosclerosis | Zendy

Christian A. Gleissner | Zendy; John M. Sanders | Zendy; Jerry L. Nadler | Zendy; Klaus Ley | Zendy

Open Access

Upregulation of Aldose Reductase During Foam Cell Formation as Possible Link Among Diabetes, Hyperlipidemia, and Atherosclerosis

Author(s) -

Christian A. Gleissner,

John M. Sanders,

Jerry L. Nadler,

Klaus Ley

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.107.158295

Subject(s) - aldose reductase , downregulation and upregulation , hyperlipidemia , foam cell , diabetes mellitus , medicine , chemistry , endocrinology , biochemistry , cholesterol , lipoprotein , gene

Aldose reductase (AR) is the rate-limiting enzyme of the polyol pathway. In diabetes, it is related to microvascular complications. We discovered AR expression in foam cells by gene chip screening and hypothesized that it may be relevant in atherosclerosis.

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