Dietary Cholesterol Worsens Adipose Tissue Macrophage Accumulation and Atherosclerosis in Obese LDL Receptor–Deficient Mice | Zendy

Savitha Subramanian | Zendy; Chang Yeop Han | Zendy; Tsuyoshi Chiba | Zendy; Timothy S. McMillen | Zendy; Shari A. Wang | Zendy; Antonio Haw | Zendy; Elizabeth A. Kirk | Zendy; Kevin D. O’Brien | Zendy; Alan Chait | Zendy

Open Access

Dietary Cholesterol Worsens Adipose Tissue Macrophage Accumulation and Atherosclerosis in Obese LDL Receptor–Deficient Mice

Author(s) -

Savitha Subramanian,

Chang Yeop Han,

Tsuyoshi Chiba,

Timothy S. McMillen,

Shari A. Wang,

Antonio Haw,

Elizabeth A. Kirk,

Kevin D. O’Brien,

Alan Chait

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.107.157685

Subject(s) - adipose tissue , medicine , endocrinology , inflammation , insulin resistance , cholesterol , adipocyte , systemic inflammation , ldl receptor , serum amyloid a , obesity , lipoprotein

Chronic systemic inflammation accompanies obesity and predicts development of cardiovascular disease. Dietary cholesterol has been shown to increase inflammation and atherosclerosis in LDL receptor-deficient (LDLR(-/-)) mice. This study was undertaken to determine whether dietary cholesterol and obesity have additive effects on inflammation and atherosclerosis.

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