Oleate Induces a Myofibroblast-Like Phenotype in Mesangial Cells | Zendy

Rangnath Mishra | Zendy; Michael S. Simonson | Zendy

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Oleate Induces a Myofibroblast-Like Phenotype in Mesangial Cells

Author(s) -

Rangnath Mishra,

Michael S. Simonson

Publication year - 2007

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.107.157339

Subject(s) - myofibroblast , fibronectin , microbiology and biotechnology , extracellular matrix , transforming growth factor beta , secretion , transforming growth factor , actin , biology , chemistry , endocrinology , medicine , fibrosis

High circulating free fatty acids, commonly associated with obesity and insulin resistance, impair structure and function of the microvasculature. However, the mechanisms by which fatty acids cause microvascular remodeling are unclear. Using the mesangial cell model of microvascular pericytes, we demonstrate that the monounsaturated free fatty acid oleate induces a myofibroblast phenotype, an important cell fate transition in fibrotic remodeling of the extracellular matrix.

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