Cholesterol Synthesis Inhibition Elicits an Integrated Molecular Response in Human Livers Including Decreased ACAT2 | Zendy

Paolo Parini | Zendy; Ulf Gustafsson | Zendy; Matt A. Davis | Zendy; Lilian Larsson | Zendy; Curt Einarsson | Zendy; Martha D. Wilson | Zendy; Mats Rudling | Zendy; Hiroshi Tomoda | Zendy; Satoshi Ōmura | Zendy; Staffan Sahlin | Zendy; Bo Angelin | Zendy; Lawrence L. Rudel | Zendy; Mats Eriksson | Zendy

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Cholesterol Synthesis Inhibition Elicits an Integrated Molecular Response in Human Livers Including Decreased ACAT2

Author(s) -

Paolo Parini,

Ulf Gustafsson,

Matt A. Davis,

Lilian Larsson,

Curt Einarsson,

Martha D. Wilson,

Mats Rudling,

Hiroshi Tomoda,

Satoshi Ōmura,

Staffan Sahlin,

Bo Angelin,

Lawrence L. Rudel,

Mats Eriksson

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.107.157172

Subject(s) - lathosterol , medicine , endocrinology , cholesterol , fluvastatin , hmg coa reductase , apolipoprotein b , hydroxymethylglutaryl coa reductase , atorvastatin , statin , ldl receptor , liver x receptor , apolipoprotein e , reverse cholesterol transport , reductase , abcg1 , chemistry , receptor , very low density lipoprotein , abca1 , lipoprotein , sterol , simvastatin , biochemistry , enzyme , nuclear receptor , disease , transporter , campesterol , gene , transcription factor

The purpose of this study was to identify how different degrees of cholesterol synthesis inhibition affect human hepatic cholesterol metabolism.

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