Open AccessAdiponectin Protects Against Angiotensin II–Induced Cardiac Fibrosis Through Activation of PPAR-α
Author(s) -
Koichi Fujita,
Norikazu Maeda,
Mina Sonoda,
Koji Ohashi,
Toshiyuki Hibuse,
Hitoshi Nishizawa,
Makoto Nishida,
Aki Hiuge,
Akifumi Kurata,
Shinji Kihara,
Iichiro Shimomura,
Tohru Funahashi
Publication year - 2008
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.156687
Subject(s) - adiponectin , medicine , endocrinology , cardiac fibrosis , ampk , angiotensin ii , fibrosis , peroxisome proliferator activated receptor , protein kinase a , knockout mouse , chemistry , kinase , receptor , biochemistry , diabetes mellitus , insulin resistance
Adiponectin is recognized as an antidiabetic, antiatherosclerotic, and anti-inflammatory protein derived from adipocytes. However, the role of adiponectin in cardiac fibrosis remains uncertain. We herein explore the effects of adiponectin on cardiac fibrosis induced by angiotensin II (Ang II).
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