Open AccessAngiotensin II Type 1 Receptor 1166C Polymorphism Is Associated With Abdominal Aortic Aneurysm in Three Independent Cohorts
Author(s) -
Gregory T. Jones,
Andrew R. Thompson,
Frank M. van Bockxmeer,
Hany Hafez,
Jackie A. Cooper,
Jonathan Golledge,
Steve E. Humphries,
Paul E. Norman,
André M. van Rij
Publication year - 2008
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.155564
Subject(s) - abdominal aortic aneurysm , angiotensin ii , medicine , aortic aneurysm , cardiology , receptor , polymorphism (computer science) , aneurysm , endocrinology , aorta , biology , surgery , allele , genetics , gene
Although polymorphic variations in genes of the RAS system have previously been associated with susceptibility to AAA, such studies have been significantly limited by small sample sizes. This study was undertaken, using the largest case series yet reported, to determine whether common genetic variants of the RAS are associated with either susceptibility or severity of AAA.
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