Decreased Paraoxonase-2 Expression in Human Carotids During the Progression of Atherosclerosis | Zendy

Giuliana Fortunato | Zendy; Maria Donata Di Taranto | Zendy; Umberto Marcello Bracale | Zendy; Luca del Guercio | Zendy; Francesca Carbone | Zendy; Cristina Mazzaccara | Zendy; Alberto Morgante | Zendy; Francesco Paolo D’Armiento | Zendy; Maria D’Armiento | Zendy; Massimo Porcellini | Zendy; Lucia Sacchetti | Zendy; G Bracale | Zendy; Francesco Salvatore | Zendy

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Decreased Paraoxonase-2 Expression in Human Carotids During the Progression of Atherosclerosis

Author(s) -

Giuliana Fortunato,

Maria Donata Di Taranto,

Umberto Marcello Bracale,

Luca del Guercio,

Francesca Carbone,

Cristina Mazzaccara,

Alberto Morgante,

Francesco Paolo D’Armiento,

Maria D’Armiento,

Massimo Porcellini,

Lucia Sacchetti,

G Bracale,

Francesco Salvatore

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.107.154658

Subject(s) - medicine , pathology , fetus , carotid endarterectomy , immunohistochemistry , oxidative stress , pathogenesis , inflammation , real time polymerase chain reaction , carotid arteries , biology , gene , pregnancy , biochemistry , genetics

Many gene products involved in oxidation and inflammation are implicated in the pathogenesis of atherosclerosis. We investigated paraoxonase 2 (PON2), 5-lipoxygenase (5-LO), and 5-LO activating protein (FLAP) expression and malondialdehyde (MDA) levels in carotid lesions to assess their involvement in plaque formation.

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