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Aortic calcification is prevalent in type II diabetes (T2DM), enhancing morbidity and tracking metabolic syndrome parameters. Ldlr(-/-) mice fed high-fat "Westernized" diets (HFD) accumulate aortic calcium primarily in the tunica media, mediated via osteogenic morphogens and transcriptional programs that induce aortic alkaline phosphatase (ALP). Because elevated TNF-alpha is characteristic of obesity with T2DM, we examined contributions of this inflammatory cytokine.

AorticMsx2-WntCalcification Cascade Is Regulated by TNF-α–Dependent Signals in DiabeticLdlr−/−Mice

AorticMsx2-WntCalcification Cascade Is Regulated by TNF-α–Dependent Signals in DiabeticLdlr^−/−Mice