Open AccessAortic Msx2-Wnt Calcification Cascade Is Regulated by TNF-α–Dependent Signals in Diabetic Ldlr −/− Mice
Author(s) -
Ziyad AlAly,
Jian-Su Shao,
ChungFang Lai,
Emily Huang,
Jun Cai,
Abraham Behrmann,
SuLi Cheng,
Dwight A. Towler
Publication year - 2007
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.153668
Subject(s) - calcification , medicine , ldl receptor , endocrinology , tumor necrosis factor alpha , wnt signaling pathway , biology , chemistry , microbiology and biotechnology , cholesterol , signal transduction , lipoprotein
Aortic calcification is prevalent in type II diabetes (T2DM), enhancing morbidity and tracking metabolic syndrome parameters. Ldlr(-/-) mice fed high-fat "Westernized" diets (HFD) accumulate aortic calcium primarily in the tunica media, mediated via osteogenic morphogens and transcriptional programs that induce aortic alkaline phosphatase (ALP). Because elevated TNF-alpha is characteristic of obesity with T2DM, we examined contributions of this inflammatory cytokine.
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