Open AccessEpoxyeicosatrienoic Acids Regulate Trp Channel–Dependent Ca 2+ Signaling and Hyperpolarization in Endothelial Cells
Author(s) -
Ingrid Fleming,
Alexandra Rueben,
Rüdiger Popp,
Beate Fißlthaler,
Susanne Schrodt,
Anna Sander,
Judith Haendeler,
John R. Falck,
Christophe Morisseau,
Bruce D. Hammock,
Rudi Busse
Publication year - 2007
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.152074
Subject(s) - hyperpolarization (physics) , bradykinin , apamin , epoxyeicosatrienoic acid , microbiology and biotechnology , iberiotoxin , charybdotoxin , cyclopiazonic acid , endothelial stem cell , chemistry , potassium channel , intracellular , biology , biochemistry , biophysics , membrane potential , arachidonic acid , receptor , stereochemistry , enzyme , nuclear magnetic resonance spectroscopy , in vitro
An initial step in endothelium-derived hyperpolarizing factor-mediated responses is endothelial cell hyperpolarization. Here we address the mechanisms by which cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) contribute to this effect in native and cultured endothelial cells.
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