Open AccessExpression of HIF-1α in Injured Arteries Controls SDF-1α–Mediated Neointima Formation in Apolipoprotein E–Deficient Mice
Author(s) -
Ela Karshovska,
Alma Zernecke,
Gueler Sevilmis,
Andrea Millet,
Mihail Hristov,
Clemens D. Cohen,
Holger Schmid,
Florian Krötz,
HaeYoung Sohn,
Volker Klauß,
Christian Weber,
Andreas Schober
Publication year - 2007
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.151050
Subject(s) - neointima , progenitor cell , stromal cell , downregulation and upregulation , neointimal hyperplasia , restenosis , microbiology and biotechnology , chemistry , medicine , biology , stem cell , stent , biochemistry , gene
Hypoxia-inducible factor (HIF)-1alpha is the regulatory subunit of a transcriptional complex, which controls the recruitment of multipotent progenitor cells and tissue repair in ischemic tissue by inducing stromal cell-derived factor (SDF)-1alpha expression. Because HIF-1alpha can be activated under normoxic conditions in smooth muscle cells (SMCs) by platelet products, we investigated the role of HIF-1alpha in SDF-1alpha-mediated neointima formation after vascular injury.
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