Platelet Activation by Oxidized Low Density Lipoprotein Is Mediated by Cd36 and Scavenger Receptor-A | Zendy

Suzanne J.A. Korporaal | Zendy; Miranda Van Eck | Zendy; Jelle Adelmeijer | Zendy; Martin J. W. IJsseldijk | Zendy; Ruud Out | Zendy; Ton Lisman | Zendy; Peter J. Lenting | Zendy; Theo J.C. van Berkel | Zendy; JanWillem N. Akkerman | Zendy

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Platelet Activation by Oxidized Low Density Lipoprotein Is Mediated by Cd36 and Scavenger Receptor-A

Author(s) -

Suzanne J.A. Korporaal,

Miranda Van Eck,

Jelle Adelmeijer,

Martin J. W. IJsseldijk,

Ruud Out,

Ton Lisman,

Peter J. Lenting,

Theo J.C. van Berkel,

JanWillem N. Akkerman

Publication year - 2007

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.107.150698

Subject(s) - scavenger receptor , cd36 , low density lipoprotein , platelet activation , scavenger , chemistry , receptor , lipoprotein , platelet , medicine , endocrinology , biochemistry , microbiology and biotechnology , pharmacology , biophysics , biology , cholesterol , radical

The interaction of platelets with low density lipoprotein (LDL) contributes to the development of cardiovascular disease. Platelets are activated by native LDL (nLDL) through apoE Receptor 2' (apoER2')-mediated signaling to p38(MAPK) and by oxidized LDL (oxLDL) through lysophosphatidic acid (LPA) signaling to Rho A and Ca2+. Here we report a new mechanism for platelet activation by oxLDL.

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