Association of OAZ1 Gene Polymorphisms With Subclinical and Clinical Vascular Events
Author(s) -
Julie Dumont,
Mahmoud Zureik,
Christophe Bauters,
Marie-Catherine Grupposo,
Dominique Cottel,
Michèle Montaye,
Martial Hamon,
Pierre Ducimetière,
Philippe Amouyel,
Thierry Brousseau
Publication year - 2007
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.150458
Subject(s) - allele , vascular smooth muscle , medicine , restenosis , biology , vascular disease , endocrinology , gene , genetics , stent , smooth muscle
Proliferation and migration of vascular smooth muscle cells (VSMCs) are striking features shared by vascular ageing, atherosclerosis, and in-stent restenosis. VSMC biology depends in part on polyamines whose metabolism is closely regulated by ornithine decarboxylase antizyme 1 (OAZ1). Therefore, we sought for association between OAZ1 gene polymorphisms and various outcomes involving VSMC proliferation.
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