Open AccessDefective Leptin/Leptin Receptor Signaling Improves Regulatory T Cell Immune Response and Protects Mice From Atherosclerosis
Author(s) -
Soraya Taleb,
Olivier Herbin,
Hafid AitOufella,
Wim Verreth,
Pierre Gourdy,
Véronique Barateau,
Régine Merval,
Bruno Esposito,
Karine Clément,
Paul Holvoet,
Alain Tedgui,
Ziad Mallat
Publication year - 2007
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.149567
Subject(s) - foxp3 , leptin , immune system , endocrinology , ldl receptor , medicine , leptin receptor , biology , receptor , cytokine , regulatory t cell , immunology , t cell , cholesterol , lipoprotein , il 2 receptor , obesity
Obesity is a major risk factor for atherosclerosis and is associated with increased cardiovascular morbidity and mortality. However, the precise molecular pathways responsible for this close association remain poorly understood.
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