Open AccessImportant Role of Nox4 Type NADPH Oxidase in Angiogenic Responses in Human Microvascular Endothelial Cells In Vitro
Author(s) -
Srinivasa Raju Datla,
Hitesh Peshavariya,
Gregory J. Dusting,
Kalyankar Mahadev,
Barry J. Goldstein,
Fan Jiang
Publication year - 2007
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.149450
Subject(s) - nox4 , nadph oxidase , microbiology and biotechnology , angiogenesis , biology , nad(p)h oxidase , mapk/erk pathway , umbilical vein , endothelial stem cell , tyrosine kinase , chemistry , signal transduction , cancer research , reactive oxygen species , in vitro , biochemistry
Redox signaling mediated by Nox2-containing NADPH oxidase has been implicated in angiogenic responses both in vitro and in vivo. Because Nox4 type NADPH oxidase is also highly expressed in endothelial cells, we studied the role of Nox4 in angiogenic responses in human endothelial cells in culture.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom