Open AccessRole of Osteoprotegerin in Arterial Calcification
Author(s) -
Yuichi Orita,
Hideya Yamamoto,
Nobuoki Kohno,
Masaaki Sugihara,
Hiroaki Honda,
Seiichi Kawamata,
Shinji Mito,
Nwe Nwe Soe,
Masao Yoshizumi
Publication year - 2007
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.147868
Subject(s) - osteoprotegerin , calcification , calcitriol , aorta , medicine , vascular smooth muscle , endocrinology , chemistry , alkaline phosphatase , calcium , lesion , bone resorption , downregulation and upregulation , pathology , smooth muscle , biochemistry , enzyme , receptor , activator (genetics) , gene
Enhanced osteoclastogenesis, increased bone resorption, and osteoporosis have been reported in osteoprotegerin-deficient (OPG (-/-)) mice. OPG (-/-) mice available in Japan usually do not show vascular calcification. We have found that arterial calcification can be quickly induced by a simple procedure in OPG (-/-) mice.
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